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Diabetes Disorder Postulation
Hypotheses - Diabetes is a disorder afflicting every cell in the human body, consequent to the disruption of normal carbohydrate metabolism. The breakdown in the production of ATP leads to decreased mitosis, which increase the inflammatory processes that lead to neuropathies, poor wound healing, vascular disorders, kidney and retinal (eye) damage, as well as decreased energy, depression and a greatly reduced quality of life, and ultimately manifest as multi-system failure,.
Even with the desired and best “tight control” of elevated blood sugar in both Type 1 and Type 2 diabetes, the complications (or co-morbidities) of diabetes often continue to progress, resulting in premature mortality. Conventional, sustained subcutaneous insulin therapy is postulated to saturate and “stun” insulin receptors in the mitochondria, decreasing ATP (energy) production. Serum glucose and HbA1c are limited markers, as they don’t directly reflect the metabolic core problem.
The normal pancreas delivers insulin via a remarkable coordinated pulse of insulin from the beta cells every 5-6 minutes in response to a carbohydrate challenge. This pulse is thought to be the metabolic trigger for the liver to begin storing glucose as glycogen and to initiate an enzymatic cascade to allow insulin and glucose into intracellular mitochondria to produce ATP (energy) to stimulate muscle, nerve, and cells throughout the body .
In both T1 and T2 diabetes this process is impaired.
Various researchers have hypothesized that “physiologic” pulse insulin delivers the vital hormone while allowing the cellular receptors to recover between pulses, preventing insulin resistance in T2 diabetes, and allowing the mitochondria in cells to function normally in both T1 and T2 diabetes in their metaboliism of carbohydrates.
Diabetes Metabolic Restorative Therapy (DMRT), which utilizes pulsatile insulin infusion, along with education and other care innovations, basically mimics the normal pancreas’ functions in stimulating the liver and virtually all cells in the body to process carbohydrates normally.
There is more basic science research needed to fully understand these mechanisms, but numerous citations attest to the likely validity of the hypotheses.